关键通路与核心分子

方法：综合联合富集、GSEA、通路耦合和已知配对，给全部通路打分。

结果：排名第一的是 Flavonoid biosynthesis。共选出 14 条关键通路，每条都有样本热图和相关热图。

rank	pid	name	n_co_enriched	n_joint_sig	n_gsea_both	coupling_r	coupling_within	known_pairs	score
1	00941	Flavonoid biosynthesis	6	15	1	0.4621	0.06848	78	0.9766
2	00400	Phenylalanine, tyrosine and tryptophan biosynthesis	1	1	0	-0.1322	-0.323	71	0.7993
3	00940	Phenylpropanoid biosynthesis	0	4	0	-0.2966	-0.172	328	0.7697
4	00600	Sphingolipid metabolism	0	1	0	-0.3862	-0.4454	88	0.7566
5	00350	Tyrosine metabolism	0	2	0	-0.258	-0.1927	61	0.7317
6	00360	Phenylalanine metabolism	0	2	0	-0.1968	-0.2406	95	0.7262
7	00480	Glutathione metabolism	0	1	0	0.26	0.335	36	0.7179
8	00950	Isoquinoline alkaloid biosynthesis	0	3	0	0.174	-0.2479	38	0.7055
9	00520	Amino sugar and nucleotide sugar metabolism	0	1	0	-0.07191	-0.05861	173	0.7041
11	00053	Ascorbate and aldarate metabolism	0	7	0	0.04773	-0.04914	69	0.6986
13	00130	Ubiquinone and other terpenoid-quinone biosynthesis	0	10	0	0.1853	-0.07699	15	0.6855
14	00380	Tryptophan metabolism	0	1	0	0.1434	-0.3383	22	0.6745
16	00960	Tropane, piperidine and pyridine alkaloid biosynthesis	0	3	0	0.0324	-0.0102	28	0.6662
40	00541	Biosynthesis of various nucleotide sugars	0	1	0			30	0.5986

核心分子预览前 60 行下载全表

pid	omics	id	name	ko	n_de	module	kME	hub	o2	known	core
00130	met	NEG_q48	4-Hydroxybenzoic Acid		17	brown	0.9315	是	0.05676	是	0.9333
00940	gene	Ac_DH066619_chr1_02645		K09753	27	blue	0.9603	是	0.02235	是	0.8965
00520	gene	Ac_DH066619_chr7_01664		K00844	25	blue	0.9321	是	0.02151	是	0.896
00053	gene	Ac_DH066619_chr2_02309		K00128	27	yellow	0.906	是	0.02173	是	0.896
00940	gene	Ac_DH066619_chr7_00626		K09753	28	yellow	0.9019	是	0.0209	是	0.8947
00053	gene	Ac_DH066619_chr5_03081		K00128	25	yellow	0.9539	是	0.02304	是	0.8947
00053	gene	Ac_DH066619_chr3_04355		K00469	25	yellow	0.9728	是	0.02287	是	0.892
00940	gene	Ac_DH066619_chr6_00708		K00430	25	yellow	0.9196	是	0.02147	是	0.8901
00520	gene	Ac_DH066619_chr3_03237		K01209	22	brown	0.9278	是	0.008836	是	0.875
00350	gene	Ac_DH066619_chr5_02834		K01593	24	red	0.9348	是	0.007007	是	0.8708
00360	gene	Ac_DH066619_chr5_02834		K01593	24	red	0.9348	是	0.007007	是	0.8673
00950	gene	Ac_DH066619_chr5_02834		K01593	24	red	0.9348	是	0.007007	是	0.8605
00480	gene	Ac_DH066619_chr2_01020		K00434	20	magenta	0.9036	是	0.013	是	0.8504
00380	gene	Ac_DH066619_chr5_02834		K01593	24	red	0.9348	是	0.007007	是	0.8486
00053	gene	Ac_DH066619_chr2_01020		K00434	20	magenta	0.9036	是	0.013	是	0.848
00350	gene	Ac_DH066619_chr5_02835		K01593	22	purple	0.91	是	0.00094	是	0.84
00940	gene	Ac_DH066619_chr5_02960		K09753	10	yellow	0.9227	是	0.02192	是	0.8386
00940	gene	Ac_DH066619_chr2_04751		K00430	16	red	0.9186	是	0.01116	是	0.8339
00360	gene	Ac_DH066619_chr5_02835		K01593	22	purple	0.91	是	0.00094	是	0.8308
00940	gene	Ac_DH066619_chr2_04752		K00430	14	red	0.9357	是	0.0109	是	0.8246
00400	gene	Ac_DH066619_chr7_01586		K15227	14	red	0.9003	是	0.004121	是	0.822
00380	gene	Ac_DH066619_chr5_02835		K01593	22	purple	0.91	是	0.00094	是	0.8139
00360	met	POS_q32	2-Phenylethylamine		7	red	0.9048	是	0.02376	是	0.8111
00950	gene	Ac_DH066619_chr5_02835		K01593	22	purple	0.91	是	0.00094	是	0.8079
00940	gene	Ac_DH066619_chr3_04146		K00430	7	red	0.9078	是	0.01195	是	0.7982
00480	met	NEG_q211	L-Glutamic Acid		0	green	0.9219	是	0.009615	是	0.7667
00130	met	NEG_q219	L-Tyrosine		0	yellow	0.9319	是	0.009686	是	0.7667
00520	gene	Ac_DH066619_chr6_01623		K01183	14	blue	0.9275	是	0	是	0.7466
00940	gene	Ac_DH066619_chr4_04502		K01904	20	blue	0.943	是	0	是	0.7421
00480	met	NEG_q207	L-Ascorbic Acid		6	brown	0.6235	否	0.04399	是	0.7333
00600	met	POS_q160	D-Erythro-Dihydrosphingosine		8	blue	0.7508	否	0.02912	是	0.7167
00400	met	POS_q95	Anthranilic Acid		17	turquoise	0.8363	否	0.05347	是	0.7125
00400	met	POS_t272	L-PHENYLALANINE		0	yellow	0.9238	是	0.014	是	0.7125
00053	met	NEG_q128	D-Glucuronic Acid Lactone		12	brown	0.7806	否	0.05135	是	0.7091
00520	met	NEG_t25	1-Phospho-alpha-D-galacturonate		8	brown	0.5808	否	0.04076	是	0.7077
00541	gene	Ac_DH066619_chr7_01320		K00963	30	yellow	0.8902	否	0.02166	是	0.7023
00520	gene	Ac_DH066619_chr7_01320		K00963	30	yellow	0.8902	否	0.02166	是	0.6994
00520	gene	Ac_DH066619_chr3_02383		K13648	25	blue	0.9518	是	0.02206	否	0.6983
00480	gene	Ac_DH066619_chr2_06155		K00036	29	blue	0.9092	是	0.02244	否	0.6973
00350	gene	Ac_DH066619_chr6_00332		K00276	23	blue	0.8308	否	0.01921	是	0.6954
00360	gene	Ac_DH066619_chr6_00332		K00276	23	blue	0.8308	否	0.01921	是	0.6942
00380	gene	Ac_DH066619_chr2_02309		K00128	27	yellow	0.906	是	0.02173	否	0.6931
00350	gene	Ac_DH066619_chr1_00689		K01593	29	yellow	0.5584	否	0.01513	是	0.6923
00940	gene	Ac_DH066619_chr3_02670		K01904	27	blue	0.8746	否	0.0204	是	0.6918
00360	gene	Ac_DH066619_chr1_00689		K01593	29	yellow	0.5584	否	0.01513	是	0.6904
00380	gene	Ac_DH066619_chr5_03081		K00128	25	yellow	0.9539	是	0.02304	否	0.6903
00130	gene	Ac_DH066619_chr3_05149		K09833	25	yellow	0.987	是	0.0229	否	0.6894
00480	gene	Ac_DH066619_chr3_04433		K00799	25	yellow	0.9806	是	0.02295	否	0.6894
00600	gene	Ac_DH066619_chr1_04516		K04713	21	yellow	0.7368	否	0.01689	是	0.6887
00960	gene	Ac_DH066619_chr8_02945		K08081	25	blue	0.9621	是	0.02294	否	0.6886
00960	gene	Ac_DH066619_chr8_00409		K08081	29	yellow	0.9531	是	0.0221	否	0.6886
00380	gene	Ac_DH066619_chr7_03249		K23947	26	yellow	0.9022	是	0.02049	否	0.6875
00950	gene	Ac_DH066619_chr1_00689		K01593	29	yellow	0.5584	否	0.01513	是	0.6868
00053	gene	Ac_DH066619_chr4_01386		K00434	25	yellow	0.7382	否	0.01772	是	0.6867
00130	gene	Ac_DH066619_chr7_03083		K06127	25	blue	0.9648	是	0.02259	否	0.6864
00600	gene	Ac_DH066619_chr4_01200		K04713	19	blue	0.8293	否	0.02063	是	0.6859
00480	gene	Ac_DH066619_chr8_00678		K00036	25	yellow	0.9271	是	0.02205	否	0.6858
00940	gene	Ac_DH066619_chr4_02450		K01904	25	yellow	0.8626	否	0.01953	是	0.6854
00350	gene	Ac_DH066619_chr5_02837		K01593	20	black	0.6035	否	0.01663	是	0.6846
00960	gene	Ac_DH066619_chr7_00383		K08081	25	blue	0.95	是	0.02269	否	0.6841

关键通路与核心分子?

每条关键通路

关键通路与核心分子

分析目的

输入数据

分析方法

结果怎么看

关键通路排名

关键通路

核心分子

ko00941 Flavonoid biosynthesis 样本热图

ko00941 Flavonoid biosynthesis 相关热图

ko00941 Flavonoid biosynthesis 成员

ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 样本热图

ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 相关热图

ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 成员

ko00940 Phenylpropanoid biosynthesis 样本热图

ko00940 Phenylpropanoid biosynthesis 相关热图

ko00940 Phenylpropanoid biosynthesis 成员

ko00600 Sphingolipid metabolism 样本热图

ko00600 Sphingolipid metabolism 相关热图

ko00600 Sphingolipid metabolism 成员

ko00350 Tyrosine metabolism 样本热图

ko00350 Tyrosine metabolism 相关热图

ko00350 Tyrosine metabolism 成员

ko00360 Phenylalanine metabolism 样本热图

ko00360 Phenylalanine metabolism 相关热图

ko00360 Phenylalanine metabolism 成员

ko00480 Glutathione metabolism 样本热图

ko00480 Glutathione metabolism 相关热图

ko00480 Glutathione metabolism 成员

ko00950 Isoquinoline alkaloid biosynthesis 样本热图

ko00950 Isoquinoline alkaloid biosynthesis 相关热图

ko00950 Isoquinoline alkaloid biosynthesis 成员

ko00520 Amino sugar and nucleotide sugar metabolism 样本热图

ko00520 Amino sugar and nucleotide sugar metabolism 相关热图

ko00520 Amino sugar and nucleotide sugar metabolism 成员

ko00053 Ascorbate and aldarate metabolism 样本热图

ko00053 Ascorbate and aldarate metabolism 相关热图

ko00053 Ascorbate and aldarate metabolism 成员

ko00130 Ubiquinone and other terpenoid-quinone biosynthesis 样本热图

ko00130 Ubiquinone and other terpenoid-quinone biosynthesis 相关热图

ko00130 Ubiquinone and other terpenoid-quinone biosynthesis 成员

ko00380 Tryptophan metabolism 样本热图

ko00380 Tryptophan metabolism 相关热图

ko00380 Tryptophan metabolism 成员

ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 样本热图

ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 相关热图

ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 成员

ko00541 Biosynthesis of various nucleotide sugars 样本热图

ko00541 Biosynthesis of various nucleotide sugars 相关热图

ko00541 Biosynthesis of various nucleotide sugars 成员

关键通路与核心分子